Dear Editor-in-Chief, The authors would like to thank the reviewers for their valuable feedback and constructive comments. We have carefully revised the manuscript in accordance with their suggestions. Below is a detailed list of the changes implemented in response to each reviewer’s remark. For every comment, we provide a justification and indicate the corresponding modifications in the manuscript, which are highlighted in yellow for clarity. The reviewers’ reports can be found in the supplementary files. Tracking number: 866-1874 Sincerely, Oualid BOUGZIME